Tirzepatide vs. Semaglutide Side Effects — How Do They Compare?
When selecting a GLP-1 medication for weight loss, you have two options: Semaglutide, which includes popular name brands like Ozempic and Wegovy; and called tirzepatide, which includes name brands Zepbound and Mounjaro. Both varieties are effective for weight loss, but there are some slight differences. One of the more tangible differences between semaglutide and tirzepatide medications are the side effects.
Dr. Randall Turner, dual board-certified physician, D.O. says it all starts with the two medications’ chemical differences. The side effects of tirzepatide and semaglutide medications look different due to their makeup. However, they still provide comparable weight loss results — and are similarly administered as injectables.
“Semaglutide is a GLP-1 receptor agonist. This means it mimics the effects of the GLP-1 hormone to help regulate blood sugar levels and reduce appetite,” he says. “Tirzepatide, on the other hand, is a dual agonist. It works on the GLP-1 and GIP receptors (glucose-dependent insulinotropic polypeptide). Tirzepatide can enhance glucose control and appetite suppression by targeting two different hormonal pathways, giving it a broader action compared to semaglutide.”
