Simparica Trio or NexGard Spectra: The Surprising Truth About Which One Keeps Your Dog Safer and Healthier
Is your dog hosting a secret party of uninvited creepy-crawlies? If so, you’re definitely not alone—parasite infestations in our furry friends have been skyrocketing, and pet parents everywhere are scrambling for reliable solutions. At DiscountPetMart, we get it—nothing’s more worrying than those tiny invaders making a home on your beloved pooch. Among the sea of options, two treatments keep rising to the top: Simparica Trio and NexGard Spectra. But how do you pick the right one amidst the buzz? That’s where I come in. In this post, we’re diving into what sets these two apart—and why choosing wisely matters for your pup’s health and happiness. Ready to navigate this tricky terrain so your furball can stay pest-free and proud? Let’s get into it! LEARN MORE
The increasing problem of parasite infestation in dogs has led to a sharp growth in the demand for parasite control treatments among dog parents. To cater to the increasing demand, we at DiscountPetMart carry a wide range of parasite control products for you to choose from. However, if we are asked to highlight two remedies that are most popular among pet parents, they will be none other than Simparica Trio and NexGard Spectra.
In this blog, we will walk you through the differences between the treatments to help you opt for the appropriate one for your furball. Read on to find out more.
Why Compare Simparica Trio and NexGard Spectra?
Both Simparica Trio and NexGard Spectra are vet-recommended treatments that are effective against a wide range of internal and external parasites. However, the treatments are unique when it comes to composition, coverage of parasites and minimum weight criterion. Therefore, when it comes to choosing one between the two, it is important to carefully compare them so as to choose the treatment that suits your furry companion the best.
What is Simparica Trio?
Simparica Trio is a broad-spectrum parasite-control treatment formulated using Sarolaner, Moxidectin, and Pyrantel as its active ingredients. It is suitable for dogs and puppies from 8 weeks of age, weighing at least 2.8 lbs. It comes in the form of highly palatable liver-flavored oral chews and aids in easy administration.
- Parasites Covered by Simparica Trio
Simparica Trio is indicated to offer protection against parasites like fleas, lone star ticks, Gulf Coast ticks, American dog ticks, black-legged ticks, brown dog ticks, Asian longhorned ticks, heartworms, hookworms and roundworms. It is also indicated to prevent Lyme disease infections.
- Frequency of Simparica Trio
Simparica Trio should be administered once a month, preferably on the same date of each month.
What is NexGard Spectra?
NexGard Spectra is designed to protect canines against a plethora of internal and external parasites. Formulated using Afoxolaner and Milbemycin Oxime as its active ingredients, the treatment is suitable for dogs and puppies from 8 weeks of age, weighing at least 4.4 lbs. It comes in the form of tasty beef-flavored chews and helps in easy administration.
- Parasites Covered by NexGard Spectra
NexGard Spectra offers protection against fleas, brown dog ticks, Asian longhorned ticks, heartworms, mange, mites, intestinal worms like roundworms, hookworms and whipworms as well as flea tapeworms.
- Frequency of NexGard Spectra
NexGard Spectra should be administered on the same date, preferably on the same date of each month.
Simparica Trio vs. NexGard Spectra – Key Differences
Let’s take a look at the key differences between Simparica Trio and NexGard Spectra.
- Spectrum of Parasite Protection
Simparica Trio is indicated to kill fleas and treat and prevent flea infestations. It also treats and controls tick infestations caused by Gulf Coast ticks, American dog ticks, lone star ticks, deer ticks, Asian Longhorned ticks and brown dog ticks. The treatment further treats and controls adult and immature stages of roundworms and hookworms. Additionally, Simparica Trio prevents heartworm disease caused by Dirofilaria immitis and is indicated to prevent Lyme disease infections.
NexGard Spectra, on the other hand, kills fleas and treats and prevents flea infestations. It also treats and controls tick infestations caused by brown dog ticks and Asian longhorned ticks. The treatment further treats and controls mange and mites and eliminates intestinal worms like roundworms, hookworms and whipworms. It also helps in the prevention of heartworm disease.
- Duration of Effectiveness
While Simparica Trio begins killing fleas within 4 hours of administration, NexGard Spectra kills fleas within 6 – 8 hours of administration.
- Mode of Administration
Both Simparica Trio and NexGard Spectra come in the form of highly palatable oral chews. Dogs accept both these treatments with ease.
The safe use of Simparica Trio has not been evaluated in breeding, pregnant and lactating dogs. NexGard Spectra, on the other hand, can be used in breeding, pregnant and lactating dogs.
Simparica Trio vs. NexGard Spectra
Here’s a comparative analysis between Simparica Trio and NexGard Spectra.

Frequently Asked Questions
- Which dogs should take Simparica Trio?
Simparica Trio is suitable for dogs and puppies from 8 weeks of age, weighing at least 2.8 lbs. However, its safety has not been evaluated in breeding, pregnant and lactating dogs. Use it with caution in dogs with a history of seizures or other neurologic disorders.
- Which dogs should be given NexGard Spectra?
NexGard Spectra has been designed for canines from 8 weeks of age, weighing at least 4.4 lbs. It can also be safely used in breeding, pregnant and lactating dogs.
- Which is more affordable? Simparica Trio or NexGard Spectra?
Both Simparica Trio and NexGard Spectra are reasonably priced at DiscountPetMart, as we always strive to provide every pet parent with true value for every dollar spent. All of our prices reflect our goal of providing you with the highest-quality products. To check prices, please visit DiscountPetMart.
- Can I use Simparica Trio and NexGard Spectra simultaneously on my dog?
Simparica Trio and NexGard Spectra are not recommended to be administered simultaneously in dogs, as it may lead to overlapping of coverage.
Conclusion
Simparica Trio and NexGard are highly effective vet-recommended treatments for dogs. However, they differ when it comes to parasite coverage, compositions as well as age and weight criteria.
Both Simparica Trio and NexGard Spectra are available at DiscountPetMart at discounted prices. Visit us today to enjoy unbeatable deals on your preferred parasite-control treatment from the comfort of your home.
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