Simparica vs. Frontline Plus: Which Flea Fighter Hides the Shocking Truth Your Vet Isn’t Telling You?
Ever wonder why those tiny little vampires and creepers—fleas and ticks—seem so hellbent on turning our beloved pups into their personal smorgasbord? It’s like these pesky parasites have a sixth sense for sniffing out the coziest spot on Fido’s fur, ready to launch an all-out invasion that leaves our four-legged friends itching, scratching, and risking some nasty infections. As a devoted dog parent myself, I know there’s nothing more heart-wrenching than seeing your furry pal suffer because of these relentless critters. That’s why locking down an effective parasite control treatment isn’t just smart, it’s essential for keeping our furballs safe and happy. Today, let’s dive into a face-off between two heavyweight contenders in the flea and tick prevention ring: Simparica and Frontline Plus. Which one deserves a spot in your dog’s monthly defense lineup? Buckle up as we unpack the nitty-gritty to find out which treatment stands out for your tail-wagging companion. LEARN MORE
Dogs of all breeds and sizes are vulnerable to flea and tick infestations. These harmful organisms attack our furballs and subject them to various infections and diseases. Therefore, it becomes crucial for all dog parents to use effective parasite control treatments to keep the pesky organisms at bay.
In this blog, we will discuss two popular flea and tick treatments for dogs, Simparica vs. Frontline Plus. We will also take you through a detailed comparison between the two remedies to help you spy the one that suits your furry companion. Let’s get started.
Simparica vs. Frontline Plus – A Quick Glance
Simparica Chewables for Dogs
Simparica comes in the form of flavored chews, indicated to treat and prevent flea infestations. The treatment also treats and controls tick infestations caused by lone star ticks, Gulf Coast ticks, American dog ticks, black-legged ticks, brown dog ticks and Asian longhorned ticks. It also prevents Lyme disease due to the direct result of killing black-legged ticks. Simparica Chewables for Dogs is a monthly treatment and is suitable for dogs and puppies from 6 months of age, weighing at least 2.8 lbs.
Frontline Plus for Dogs
Frontline Plus comes in the form of a topical treatment indicated to kill adult fleas, flea eggs and flea larvae. It also prevents all flea stages from developing and kills fleas, which may cause flea allergy dermatitis. The treatment also kills all life stages of ticks, including Brown dog ticks, lone star ticks, American dog ticks and black-legged ticks. It further kills ticks that may transfer Lyme disease, Rocky Mountain Spotted Fever and other tick-borne diseases. Additionally, Frontline Plus helps in the elimination of chewing lice and sarcoptic mange infestations. It is designed for monthly infestation and is suitable for dogs and puppies from 8 weeks of age, weighing at least 5 lbs.
Similarities & Differences
Here are the key similarities and differences between Simparica and Frontline Plus.
Similarities:
- Both Simparica and Frontline Plus are indicated to treat and prevent flea infestations.
- Each of them is effective against tick infestations caused by lone star ticks, black-legged ticks, American dog ticks and brown dog ticks.
- Both treatments kill ticks that may transmit Lyme disease.
- Both of them are designed for monthly administration.
Differences:
- While Simparica is an oral chew, Frontline Plus is a topical treatment.
- Simparica is formulated to treat and control Gulf Coast ticks and Asian longhorned ticks. Frontline Plus is not known to be effective against these tick species.
- Frontline Plus helps eliminate chewing lice and sarcoptic mange infestations. But Simparica doesn’t.
- Simparica is designed for dogs and puppies from 6 months of age, weighing at least 2.8 lbs. Frontline Plus, on the other hand, is suitable for canines from 8 weeks of age, weighing at least 5 lbs.
- While Simparica is formulated using sarolaner as its active ingredient, Frontline Plus features fipronil and (S)-methoprene as its active ingredients.
- The safe use of Simparica has not been evaluated in breeding, pregnant and lactating dogs. However, Frontline Plus is approved for use in breeding, pregnant and lactating queens.
Comparative Analysis:
Let’s take a look at a detailed comparison of the key features of Simparica and Frontline Plus

Wrapping Up
Both Simparica and Frontline Plus are vet-recommended treatments that protect dogs and puppies against a range of external parasites. However, they differ when it comes to mode of application, compositions, parasite coverage, as well as age and weight criteria.
If you want to protect your canine against fleas and tick species like lone star ticks, black-legged ticks, American dog ticks or brown dog ticks, you can use either of the treatments. But if you want protection against Gulf Coast ticks and Asian longhorned ticks, you should go for Simparica. And if your pooch is infested with chewing lice or sarcoptic mange, you should opt for Frontline Plus. However, make sure that your furry baby meets the minimum age andweight requirements specified on the product labels of the treatments.
You can procure both Simparica and Frontline Plus at the best prices from DiscountPetMart. Check out our online store to enjoy unbeatable deals on a wide range of pet treatments and essentials from the comfort of your home.
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